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Association of polymorphisms within the transforming growth factor-β1 gene with diabetic nephropathy and serum cholesterol and triglyceride concentrations.

Nephrology (Carlton, Vic.) - 1 Sept 2010

Valladares-Salgado Adán, Angeles-Martínez Javier, Rosas Marisol, García-Mena Jaime, Utrera-Barillas Dolores, Gómez-Díaz Rita, Escobedo-de la Peña Jorge, Parra Esteban J, Cruz Miguel

Abstract excerpt

AIM: The TGF-β gene participates in the development of chronic kidney disease. We investigated whether the 869 T > C, 915 G > C and -800 G > A polymorphisms of TGF-β1 are associated with diabetic nephropathy (DN). METHODS: Polymorphisms were genotyped in 439 type 2 diabetes mellitus patients, 233 with diabetic nephropathy (DN+) and 206 without (DN-). The sample was characterized for relevant clinical and...

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PMID: 20883286
DOI: 10.1111/j.1440-1797.2010.01302.x

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