Article
Association of TGFbeta1, TNFalpha, CCR2 and CCR5 gene polymorphisms in type-2 diabetes and renal insufficiency among Asian Indians.
BMC medical genetics - 12 Apr 2007
Prasad Pushplata, Tiwari Arun K, Kumar K M Prasanna, Ammini A C, Gupta Arvind, Gupta Rajeev, Thelma B K
Abstract excerpt
BACKGROUND: Cytokines play an important role in the development of diabetic chronic renal insufficiency (CRI). Transforming growth factor beta1 (TGF beta1) induces renal hypertrophy and fibrosis, and cytokines like tumor necrosis factor-alpha (TNFalpha), chemoattractant protein-1 (MCP-1), and reg...
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