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Article

Substitution of tryptophan 89 with tyrosine switches the DNA binding mode of PC4.

Scientific reports - 5 Mar 2015

Huang Jinguang, Zhao Yanxiang, Liu Huaian, Huang Dan, Cheng Xiankun, Zhao Wensheng, Taylor Ian A, Liu Junfeng, Peng You-Liang

Abstract excerpt

PC4, a well-known general transcription cofactor, has multiple functions in transcription and DNA repair. Residue W89, is engaged in stacking interactions with DNA in PC4, but substituted by tyrosine in some PC4 orthologous proteins. In order to understand the consequences and reveal the molecular details of this substitution we have determined the crystal structures of the PC4 orthologue MoSub1 and a PC4 W89Y...

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Identifiers

PMID: 25739870
DOI: 10.1038/srep08789
PMCID: PMC4350104

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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