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Article

Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers.

Genes & development - 15 Aug 2003

Reményi Attila, Lins Katharina, Nissen L Johan, Reinbold Rolland, Schöler Hans R, Wilmanns Matthias

Abstract excerpt

Members of the POU and SOX transcription factor families exemplify the partnerships established between various transcriptional regulators during early embryonic development. Although functional cooperativity between key regulator proteins is pivotal for milestone decisions in mammalian development, little is known about the underlying molecular mechanisms. In this study, we focus on two transcription factors,...

Topics

Animals
Base Sequence
Chromosomal Proteins, Non-Histone
Crystallography, X-Ray
DNA
DNA-Binding Proteins
Enhancer Elements, Genetic
Escherichia coli
Fibroblast Growth Factors
HMGB Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

High Mobility Group Proteins

Humans

Mice

Models, Molecular

Mutation

Nuclear Proteins

Nucleic Acid Conformation

Octamer Transcription Factor-3

Source

Open in PubMed Open full text

Identifiers

PMID: 12923055
DOI: 10.1101/gad.269303
PMCID: PMC196258

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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