Article
Differential effects of phosphorylation on DNA binding properties of N Oct-3 are dictated by protein/DNA complex structures.
Journal of molecular biology - 20 Jul 2007
Nieto Laurence, Joseph Gérard, Stella Alexandre, Henri Pauline, Burlet-Schiltz Odile, Monsarrat Bernard, Clottes Eric, Erard Monique
Abstract excerpt
N Oct-3, a transcription factor member of the POU protein family, is implicated in normal central nervous system development but also in melanoma growth. Its DNA-binding domain (DBD) comprises two subdomains, POUs and POUh, joined by a linker peptide. We have previously shown that N Oct-3 can interact with the already described PORE and MORE DNA motifs, but also with a new structural element we have termed NORE....
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