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Article

The Saccharomyces cerevisiae Mcm6/2 and Mcm5/3 ATPase active sites contribute to the function of the putative Mcm2-7 'gate'.

Nucleic acids research - 1 Oct 2010

Bochman Matthew L, Schwacha Anthony

Abstract excerpt

The Mcm2-7 complex is the eukaryotic replicative helicase, a toroidal AAA(+) molecular motor that uses adenosine triphosphate (ATP) binding and hydrolysis to separate duplex DNA strands during replication. This heterohexameric helicase contains six different and essential subunits (Mcm2 through M...

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Identifiers

PMID: 20484375
DOI: 10.1093/nar/gkq422
PMCID: PMC2952866

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20484375-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

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The Saccharomyces cerevisiae Mcm6/2 and Mcm5/3 ATPase active sites contribute to the function of the putative Mcm2-7 'gate'.PMID 20484375Read ↗

The Mcm2-7 complex has in vitro helicase activity.Semantic proximity Read ↗

ATP binding and hydrolysis by Mcm2 regulate DNA binding by Mcm complexes.Semantic proximity Read ↗

Different phenotypes in vivo are associated with ATPase motif mutations in Schizosaccharomyces pombe minichromosome maintenance proteins.Semantic proximity Read ↗

Mcm2-7 Is an Active Player in the DNA Replication Checkpoint Signaling Cascade via Proposed Modulation of Its DNA Gate.Semantic proximity Read ↗

An ORC/Cdc6/MCM2-7 complex is formed in a multistep reaction to serve as a platform for MCM double-hexamer assembly.Semantic proximity Read ↗

The ORC/Cdc6/MCM2-7 complex facilitates MCM2-7 dimerization during prereplicative complex formation.Semantic proximity Read ↗

Cdc6 ATPase activity regulates ORC x Cdc6 stability and the selection of specific DNA sequences as origins of DNA replication.Semantic proximity Read ↗

ATP hydrolysis by ORC catalyzes reiterative Mcm2-7 assembly at a defined origin of replication.Semantic proximity Read ↗

The ATPase activity of MCM2-7 is dispensable for pre-RC assembly but is required for DNA unwinding.Semantic proximity Read ↗

Functional conservation of beta-hairpin DNA binding domains in the Mcm protein of Methanobacterium thermoautotrophicum and the Mcm5 protein of Saccharomyces cerevisiae.Semantic proximity Read ↗

ATPase switches controlling DNA replication initiation.Semantic proximity Read ↗

A Meier-Gorlin syndrome mutation impairs the loading of the MCM2-7 complex during DNA replication initiation.Semantic proximity Read ↗

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