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Article

Mcm2 phosphorylation and the response to replicative stress.

BMC genetics - 7 May 2012

Stead Brent E, Brandl Christopher J, Sandre Matthew K, Davey Megan J

Abstract excerpt

BACKGROUND: The replicative helicase in eukaryotic cells is comprised of minichromosome maintenance (Mcm) proteins 2 through 7 (Mcm2-7) and is a key target for regulation of cell proliferation. In addition, it is regulated in response to replicative stress. One of the protein kinases that targets Mcm2-7 is the Dbf4-dependent kinase Cdc7 (DDK). In a previous study, we showed that alanine mutations of the DDK...

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Identifiers

PMID: 22564307
DOI: 10.1186/1471-2156-13-36
PMCID: PMC3517340

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