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Article

Cysteine reactivity distinguishes redox sensing by the heat-inducible and constitutive forms of heat shock protein 70.

Chemistry & biology - 21 Nov 2012

Miyata Yoshinari, Rauch Jennifer N, Jinwal Umesh K, Thompson Andrea D, Srinivasan Sharan, Dickey Chad A, Gestwicki Jason E

Abstract excerpt

The heat shock protein 70 (Hsp70) family of molecular chaperones has important functions in maintaining proteostasis under stress conditions. Several Hsp70 isoforms, especially Hsp72 (HSPA1A), are dramatically upregulated in response to stress; however, it is unclear whether these family members have biochemical properties that are specifically adapted to these scenarios. The redox-active compound, methylene blue...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 23177194
DOI: 10.1016/j.chembiol.2012.07.026
PMCID: PMC3508472

Genes

HSPA8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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