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Article

A structural role for the synaptobrevin 2 transmembrane domain in dense-core vesicle fusion pores.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 8 Apr 2015

Chang Che-Wei, Hui Enfu, Bai Jihong, Bruns Dieter, Chapman Edwin R, Jackson Meyer B

Abstract excerpt

Ca(2+)-triggered release of neurotransmitters and hormones depends on soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) to drive the fusion of the vesicle and plasma membranes. The formation of the SNARE complex by the vesicle SNARE synaptobrevin 2 (syb2) and the two plasma membrane SNAREs syntaxin (syx) and SNAP-25 draws the two membranes together, but the events that follow...

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Identifiers

PMID: 25855187
DOI: 10.1523/JNEUROSCI.3983-14.2015
PMCID: PMC4388931

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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