Article
Synaptotagmin-1 utilizes membrane bending and SNARE binding to drive fusion pore expansion.
Molecular biology of the cell - 1 Dec 2008
Lynch Kara L, Gerona Roy R L, Kielar Dana M, Martens Sascha, McMahon Harvey T, Martin Thomas F J
Abstract excerpt
In regulated vesicle exocytosis, SNARE protein complexes drive membrane fusion to connect the vesicle lumen with the extracellular space. The triggering of fusion pore formation by Ca(2+) is mediated by specific isoforms of synaptotagmin (Syt), which employ both SNARE complex and membrane binding. Ca(2+) also promotes fusion pore expansion and Syts have been implicated in this process but the mechanisms involved...
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