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Article

Two N-linked glycans are required to maintain the transport activity of the bile salt export pump (ABCB11) in MDCK II cells.

American journal of physiology. Gastrointestinal and liver physiology - 1 Mar 2007

Mochizuki Kaori, Kagawa Tatehiro, Numari Asano, Harris Matthew J, Itoh Johbu, Watanabe Norihito, Mine Tetsuya, Arias Irwin M

Abstract excerpt

The aim of this study was to determine the role of N-linked glycosylation in protein stability, intracellular trafficking, and bile acid transport activity of the bile salt export pump [Bsep (ATP-binding cassette B11)]. Rat Bsep was fused with yellow fluorescent protein, and the following mutants, in which Asn residues of putative glycosylation sites (Asn(109), Asn(116), Asn(122), and Asn(125)) were sequentially...

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Share to ATP Binding Cassette Transporter, Subfamily B, Member 11
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17082223
DOI: 10.1152/ajpgi.00415.2006

Genes

ABCB11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Two N-linked glycans are required to maintain the transport activity of the bile salt export pump (ABCB11) in MDCK II cells.PMID 17082223Read ↗

Phenotypic differences in PFIC2 and BRIC2 correlate with protein stability of mutant Bsep and impaired taurocholate secretion in MDCK II cells.Semantic proximity Read ↗

Bile salt export pump (BSEP/ABCB11): trafficking and sorting disturbances.Semantic proximity Read ↗

Short-chain ubiquitination is associated with the degradation rate of a cell-surface-resident bile salt export pump (BSEP/ABCB11).Semantic proximity Read ↗

Ursodeoxycholic acid stabilizes the bile salt export pump in the apical membrane in MDCK II cells.Semantic proximity Read ↗

N-glycosylation is essential for ileal ASBT function and protection against proteases.Semantic proximity Read ↗

Levels of plasma membrane expression in progressive and benign mutations of the bile salt export pump (Bsep/Abcb11) correlate with severity of cholestatic diseases.Semantic proximity Read ↗

Two common PFIC2 mutations are associated with the impaired membrane trafficking of BSEP/ABCB11.Semantic proximity Read ↗

Biosynthesis and trafficking of the bile salt export pump, BSEP: therapeutic implications of BSEP mutations.Semantic proximity Read ↗

4-phenylbutyrate enhances the cell surface expression and the transport capacity of wild-type and mutated bile salt export pumps.Semantic proximity Read ↗

Differential roles of ubiquitination in the degradation mechanism of cell surface-resident bile salt export pump and multidrug resistance-associated protein 2.Semantic proximity Read ↗

Conserved intramolecular disulfide bond is critical to trafficking and fate of ATP-binding cassette (ABC) transporters ABCB6 and sulfonylurea receptor 1 (SUR1)/ABCC8.Semantic proximity Read ↗

Compensatory role of P-glycoproteins in knockout mice lacking the bile salt export pump #Semantic proximity Read ↗

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