Article
Glycosylation and phosphorylation of lysosomal glycosylasparaginase.
Archives of biochemistry and biophysics - 1 Apr 1996
Park H, Vettese-Dadey M, Aronson N N
Abstract excerpt
Glycosylasparaginase (EC 3.5.1.26) is a lysosomal amidase which hydrolyzes the bond between asparagine and the sugar moiety in N-linked glycoproteins. Deficiency of the enzyme results in aspartylglycosaminuria (AGU), the most common disorder of glycoprotein degradation. Mature enzyme is formed by...
Topics
- Animals
- Aspartylglucosylaminase
- Base Sequence
- Biological Transport
- Brefeldin A
- Cyclopentanes
- Glycosylation
- Humans
- Lysosomes
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Oligosaccharides
- Phosphorylation
- Polymerase Chain Reaction
- Protein Folding
- Protein Processing, Post-Translational
- Protein Synthesis Inhibitors