Article
Molecular dissection of psoriasis: integrating genetics and biology.
The Journal of investigative dermatology - 1 May 2010
Elder James T, Bruce Allen T, Gudjonsson Johann E, Johnston Andrew, Stuart Philip E, Tejasvi Trilokraj, Voorhees John J, Abecasis Gonçalo R, Nair Rajan P
Abstract excerpt
Psoriasis is a common and debilitating disease of the skin, nails, and joints, with an acknowledged but complex genetic basis. Early genome-wide linkage studies of psoriasis focused on segregation of microsatellite markers in families; however, the only locus consistently identified resided in the major histocompatibility complex. Subsequently, several groups mapped this locus to the vicinity of HLA-C, and two...
Topics
- Genetic Markers
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Psoriasis