Article
Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci.
Nature communications - 5 May 2015
Tsoi Lam C, Spain Sarah L, Ellinghaus Eva, Stuart Philip E, Capon Francesca, Knight Jo, Tejasvi Trilokraj, Kang Hyun M, Allen Michael H, Lambert Sylviane, Stoll Stefan W, Weidinger Stephan, Gudjonsson Johann E, Koks Sulev, Kingo Külli, Esko Tonu, Das Sayantan, Metspalu Andres, Weichenthal Michael, Enerback Charlotta, Krueger Gerald G, Voorhees John J, Chandran Vinod, Rosen Cheryl F, Rahman Proton, Gladman Dafna D, Reis Andre, Nair Rajan P, Franke Andre, Barker Jonathan N W N, Abecasis Goncalo R, Trembath Richard C, Elder James T
Abstract excerpt
Psoriasis is a chronic autoimmune disease with complex genetic architecture. Previous genome-wide association studies (GWAS) and a recent meta-analysis using Immunochip data have uncovered 36 susceptibility loci. Here, we extend our previous meta-analysis of European ancestry by refined genotype calling and imputation and by the addition of 5,033 cases and 5,707 controls. The combined analysis, consisting of over...
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