Article
Genome-wide association analysis identifies three psoriasis susceptibility loci.
Nature genetics - 1 Nov 2010
Stuart Philip E, Nair Rajan P, Ellinghaus Eva, Ding Jun, Tejasvi Trilokraj, Gudjonsson Johann E, Li Yun, Weidinger Stephan, Eberlein Bernadette, Gieger Christian, Wichmann H Erich, Kunz Manfred, Ike Robert, Krueger Gerald G, Bowcock Anne M, Mrowietz Ulrich, Lim Henry W, Voorhees John J, Abecasis Gonçalo R, Weichenthal Michael, Franke Andre, Rahman Proton, Gladman Dafna D, Elder James T
Abstract excerpt
We carried out a meta-analysis of two recent psoriasis genome-wide association studies with a combined discovery sample of 1,831 affected individuals (cases) and 2,546 controls. One hundred and two loci selected based on P value rankings were followed up in a three-stage replication study including 4,064 cases and 4,685 controls from Michigan, Toronto, Newfoundland and Germany. In the combined meta-analysis, we...
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