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Article

Probing ADAMTS13 substrate specificity using phage display.

PloS one - 1 Jan 2015

Desch Karl C, Kretz Colin, Yee Andrew, Gildersleeve Robert, Metzger Kristin, Agrawal Nidhi, Cheng Jane, Ginsburg David

Abstract excerpt

Von Willebrand factor (VWF) is a large, multimeric protein that regulates hemostasis by tethering platelets to the subendothelial matrix at sites of vascular damage. The procoagulant activity of plasma VWF correlates with the length of VWF multimers, which is proteolytically controlled by the metalloprotease ADAMTS13. To probe ADAMTS13 substrate specificity, we created phage display libraries containing randomly...

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Source

Open in PubMed Open full text

Identifiers

PMID: 25849793
DOI: 10.1371/journal.pone.0122931
PMCID: PMC4388381

Genes

ADAMTS13
VWF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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