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Article

The WXXW motif in the TSR1 of ADAMTS13 is important for its secretion and proteolytic activity.

Thrombosis research - 1 Jun 2013

Ling Jing, Su Jian, Ma Zhenni, Ruan Changgeng

Abstract excerpt

INTRODUCTION: ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13) is a metalloprotease enzyme that regulates the size and activity of the von Willebrand factor (VWF). ADAMTS13, like many other ADAMTSs, has a WXXW motif in its thrombospondin type 1 repeat domain (TSR1). However, the function of the WXXW motif in ADAMTSs is unclear. MATERIALS AND METHODS: The constructs of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23683325
DOI: 10.1016/j.thromres.2013.04.024

Genes

ADAMTS13
VWF
TSR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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