Article

Phage Display Broadly Identifies Inhibitor-reactive Regions in von Willebrand Factor

2021-03-09

Abstract excerpt

<h4>Summary</h4> <h4>Background</h4> Correction of von Willebrand factor (VWF) deficiency with replacement products containing VWF can lead to the development of anti-VWF alloantibodies (i.e., VWF inhibitors) in patients with severe von Willebrand disease (VWD). <h4>Objective</h4> Locate inhibitor-reactive regions within VWF using phage display. <h4>Methods</h4> We screened a phage library displaying random, o...

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Literature Corpus work: b3bc6f44-5aaa-5289-a75d-5c9f7a135718
DOI: 10.1101/2021.03.08.434464

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