Article
ADAMTS13 assays and ADAMTS13-deficient mice.
Current opinion in hematology - 1 May 2007
Miyata Toshiyuki, Kokame Koichi, Banno Fumiaki, Shin Yongchol, Akiyama Masashi
Abstract excerpt
PURPOSE OF REVIEW: Thrombotic thrombocytopenic purpura can be induced by acquired or congenital deficiency of the plasma von Willebrand factor-cleaving protease, ADAMTS13. Measurement of ADAMTS13 activity is important for the diagnosis and treatment of microangiopathies including thrombotic thrombocytopenic purpura. Phenotypic analysis of mice lacking the Adamts13 gene is valuable for understanding the...
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