Article
Deep mutational scanning of the plasminogen activator inhibitor-1 functional landscape.
Scientific reports - 22 Sept 2021
Huttinger Zachary M, Haynes Laura M, Yee Andrew, Kretz Colin A, Holding Matthew L, Siemieniak David R, Lawrence Daniel A, Ginsburg David
Abstract excerpt
The serine protease inhibitor (SERPIN) plasminogen activator inhibitor-1 (PAI-1) is a key regulator of the fibrinolytic system, inhibiting the serine proteases tissue- and urokinase-type plasminogen activator (tPA and uPA, respectively). Missense variants render PAI-1 non-functional through misfolding, leading to its turnover as a protease substrate, or to a more rapid transition to the latent/inactive state....
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