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Article

The distal carboxyterminal domains of murine ADAMTS13 influence proteolysis of platelet-decorated VWF strings in vivo.

Journal of thrombosis and haemostasis : JTH - 1 Oct 2010

De Maeyer B, De Meyer S F, Feys H B, Pareyn I, Vandeputte N, Deckmyn H, Vanhoorelbeke K

Abstract excerpt

BACKGROUND: The multidomain metalloprotease ADAMTS13 regulates the size of von Willebrand factor (VWF) multimers upon their release from endothelial cells. How the different domains in ADAMTS13 control VWF proteolysis in vivo remains largely unidentified. METHODS: Seven C-terminally truncated murine ADAMTS13 (mADAMTS13) mutants were constructed and characterized in vitro. Their ability to cleave VWF strings in...

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Source

Identifiers

PMID: 20695979
DOI: 10.1111/j.1538-7836.2010.04008.x

Genes

ADAMTS13
VWF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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