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Article

The ADAMTS13 metalloprotease domain: roles of subsites in enzyme activity and specificity.

Blood - 21 Oct 2010

de Groot Rens, Lane David A, Crawley James T B

Abstract excerpt

ADAMTS13 modulates von Willebrand factor (VWF) platelet-tethering function by proteolysis of the Tyr1605-Met1606 bond in the VWF A2 domain. To examine the role of the metalloprotease domain of ADAMTS13 in scissile bond specificity, we identified 3 variable regions (VR1, -2, and -3) in the ADAMTS family metalloprotease domain that flank the active site, which might be important for specificity. Eight composite...

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Source

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Identifiers

PMID: 20647566
DOI: 10.1182/blood-2009-12-258780
PMCID: PMC2974611

Genes

ADAMTS13
VWF
ADAMTS1
ADAMTS2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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