Article
Radiological and pathological features associated with IDH1-R132H mutation status and early mortality in newly diagnosed anaplastic astrocytic tumours.
PloS one - 1 Jan 2015
Wasserman Jason K, Nicholas Garth, Yaworski Rebecca, Wasserman Anne-Marie, Woulfe John M, Jansen Gerard H, Chakraborty Santanu, Nguyen Thanh B
Abstract excerpt
BACKGROUND: Glioblastoma can occur either de novo or by the transformation of a low grade tumour; the majority of which harbor a mutation in isocitrate dehydrogenase (IDH1). Anaplastic tumours are high-grade gliomas that may represent the final step in the evolution of a secondary glioblastoma or the initial presentation of an early primary glioblastoma. We sought to determine whether pathological and/or...
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