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Article

Absence of IDH1-R132H mutation predicts rapid progression of nonenhancing diffuse glioma in older adults.

Annals of diagnostic pathology - 1 Jun 2012

Olar Adriana, Raghunathan Aditya, Albarracin Constance T, Aldape Kenneth D, Cahill Daniel P, Powell Suzanne Z, Goodman J Clay, Fuller Gregory N

Abstract excerpt

Advanced age and contrast enhancement portend a poor prognosis in diffuse glioma (DG). Diffuse glioma may present as nonenhancing tumors that rapidly progress in weeks to months to a pattern of ring enhancement, characteristic of glioblastoma (GBM). Mutations involving isocitrate dehydrogenase 1 (IDH1) have recently emerged as important diagnostic and prognostic markers in DG. R132H is the most common mutation,...

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Source

Identifiers

PMID: 22197544
DOI: 10.1016/j.anndiagpath.2011.08.010

Genes

IDH1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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