Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterizing invading glioma cells based on IDH1-R132H and Ki-67 immunofluorescence.

Brain tumor pathology - 1 Oct 2014

Sabit Hemragul, Nakada Mitsutoshi, Furuta Takuya, Watanabe Takuya, Hayashi Yutaka, Sato Hiroshi, Kato Yukinari, Hamada Jun-ichiro

Abstract excerpt

Glioma, the most common primary brain tumor, is characterized by proliferative-invasive growth. However, the detailed biological characteristics of invading glioma cells remain to be elucidated. A monoclonal antibody (clone HMab-1) that specifically and sensitively recognizes the isocitrate dehydrogenase-1 (IDH1) protein carrying the R132H mutation can identify invading glioma cells by immunostaining. To...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Neoplasms
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fluorescent Antibody Technique

Share to Glioma

Share to Isocitrate Dehydrogenase

Share to Ki-67 Antigen

Share to Neoplasm Invasiveness

Share to Neoplasm Staging

Source

Identifiers

PMID: 24384677
DOI: 10.1007/s10014-013-0172-y

Genes

IDH1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterizing invading glioma cells based on IDH1-R132H and Ki-67 immunofluorescence.PMID 24384677Read ↗

Determining IDH-Mutational Status in Gliomas Using IDH1-R132H Antibody and Polymerase Chain ReactionSemantic proximity Read ↗

Characterization of R132H mutation-specific IDH1 antibody binding in brain tumors.Semantic proximity Read ↗

Mutation analysis of IDH1 in paired gliomas revealed IDH1 mutation was not associated with malignant progression but predicted longer survival.Semantic proximity Read ↗

Radiological and pathological features associated with IDH1-R132H mutation status and early mortality in newly diagnosed anaplastic astrocytic tumours.Semantic proximity Read ↗

IDH1 mutation diminishes aggressive phenotype in glioma stem cells.Semantic proximity Read ↗

Immunohistochemical detection of IDH1 mutation, p53, and internexin as prognostic factors of glial tumors.Semantic proximity Read ↗

Isocitrate dehydrogenase 1 analysis differentiates gangliogliomas from infiltrative gliomas.Semantic proximity Read ↗

IDH1 mutation activates mTOR signaling pathway, promotes cell proliferation and invasion in glioma cells.Semantic proximity Read ↗

Application of mutant IDH1 antibody to differentiate diffuse glioma from nonneoplastic central nervous system lesions and therapy-induced changes.Semantic proximity Read ↗

R132H mutation in IDH1 gene reduces proliferation, cell survival and invasion of human glioma by downregulating Wnt/β-catenin signaling.Semantic proximity Read ↗

An IDH1-mutated primary gliosarcoma: case report.Semantic proximity Read ↗

Finding of IDH1 R132H mutation in histologically non-neoplastic glial tissue changes surgical strategies, a case report.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.