Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin.

doi:10.1200/JCO.2010.33.8715

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Article

Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Dec 2011

Lai Albert, Kharbanda Samir, Pope Whitney B, Tran Anh, Solis Orestes E, Peale Franklin, Forrest William F, Pujara Kanan, Carrillo Jose A, Pandita Ajay, Ellingson Benjamin M, Bowers Chauncey W, Soriano Robert H, Schmidt Nils O, Mohan Sankar, Yong William H, Seshagiri Somasekar, Modrusan Zora, Jiang Zhaoshi, Aldape Kenneth D, Mischel Paul S, Liau Linda M, Escovedo Cameron J, Chen Weidong, Nghiemphu Phioanh Leia, James C David, Prados Michael D, Westphal Manfred, Lamszus Katrin, Cloughesy Timothy, Phillips Heidi S

Abstract excerpt

PURPOSE: Mutation in isocitrate dehydrogenase 1 (IDH1) at R132 (IDH1(R132MUT)) is frequent in low-grade diffuse gliomas and, within glioblastoma (GBM), has been proposed as a marker for GBMs that arise by transformation from lower-grade gliomas, regardless of clinical history. To determine how GBMs arising with IDH1(R132MUT) differ from other GBMs, we undertook a comprehensive comparison of patients presenting...

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Identifiers

PMID: 22025148
DOI: 10.1200/JCO.2010.33.8715
PMCID: PMC3236649

Genes

IDH1
EGFR
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin.PMID 22025148Read ↗

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