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Article

Expression of mutated isocitrate dehydrogenase-1 in gliomas is associated with p53 and EGFR expression.

Folia neuropathologica - 1 Jan 2011

Birner Peter, Toumangelova-Uzeir Kalina, Natchev Sevdalin, Guentchev Marin

Abstract excerpt

Gliomas are the most common primary brain tumours. Several independent studies have shown that isocitrate dehydrogenase 1 (IDH1) mutation in diffuse gliomas is associated with a more favourable patient outcome. The aim of this study was to evaluate the prognostic relevance of an antibody specifically detecting the R132H point mutation of IDH1 in tissue sections in a large series of human gliomas. Surgical...

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Source

Identifiers

PMID: 21845536

Genes

EGFR
IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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