Article
Endothelin-1 critically influences cardiac function via superoxide-MMP9 cascade.
Proceedings of the National Academy of Sciences of the United States of America - 21 Apr 2015
Hathaway Catherine K, Grant Ruriko, Hagaman John R, Hiller Sylvia, Li Feng, Xu Longquan, Chang Albert S, Madden Victoria J, Bagnell C Robert, Rojas Mauricio, Kim Hyung-Suk, Wu Bingruo, Zhou Bin, Smithies Oliver, Kakoki Masao
Abstract excerpt
We have generated low-expressing and high-expressing endothelin-1 genes (L and H) and have bred mice with four levels of expression: L/L, ∼20%; L/+, ∼65%; +/+ (wild type), 100%; and H/+, ∼350%. The hypomorphic L allele can be spatiotemporally switched to the hypermorphic H allele by Cre-loxP recombination. Young adult L/L and L/+ mice have dilated cardiomyopathy, hypertension, and increased plasma volumes,...
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