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Article

Electrical remodelling precedes heart failure in an endothelin-1-induced model of cardiomyopathy.

Cardiovascular research - 15 Feb 2011

Mueller Erin E, Momen Abdul, Massé Stéphane, Zhou Yu-Qing, Liu Jie, Backx Peter H, Henkelman R Mark, Nanthakumar Kumaraswamy, Stewart Duncan J, Husain Mansoor

Abstract excerpt

AIMS: Binary transgenic (BT) mice with doxycycline (DOX)-suppressible cardiac-specific overexpression of endothelin-1 (ET-1) exhibit progressive heart failure (HF), QRS prolongation, and death following DOX withdrawal. However, the molecular basis and reversibility of the electrophysiological abnormalities in this model were not known. Here, we assess the mechanisms underlying ET-1-mediated electrical...

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Source

Identifiers

PMID: 21062919
DOI: 10.1093/cvr/cvq351

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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