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Article

Targeted deletion of MMP-9 attenuates myocardial contractile dysfunction in heart failure.

Physiological research - 1 Jan 2008

Moshal K S, Rodriguez W E, Sen U, Tyagi S C

Abstract excerpt

Chronic volume overload (VO) on the left ventricle (LV) augments redox stress and activates matrix metalloproteinase (MMP) which causes the endocardial endothelial-myocyte (EM) disconnection leading to myocardial contractile dysfunction. VO-induced MMP-9 activation impairs cardiac functions, in part by endothelial endocardial apoptosis, but the role of MMP-9 on EM functions remains obscure. We conjecture that...

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Source

Identifiers

PMID: 17552869
DOI: 10.33549/physiolres.931221

Genes

MMP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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