Article
Maternal and zygotic Zfp57 modulate NOTCH signaling in cardiac development.
Proceedings of the National Academy of Sciences of the United States of America - 21 Apr 2015
Shamis Yulia, Cullen Dana E, Liu Lizhi, Yang Guan, Ng Sheau-Fang, Xiao Lijuan, Bell Fong T, Ray Chelsea, Takikawa Sachiko, Moskowitz Ivan P, Cai Chen-Leng, Yang Xiao, Li Xiajun
Abstract excerpt
Zfp57 is a maternal-zygotic effect gene that maintains genomic imprinting. Here we report that Zfp57 mutants exhibited a variety of cardiac defects including atrial septal defect (ASD), ventricular septal defect (VSD), thin myocardium, and reduced trabeculation. Zfp57 maternal-zygotic mutant embryos displayed more severe phenotypes with higher penetrance than the zygotic ones. Cardiac progenitor cells exhibited...
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