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Article

A KRAB domain zinc finger protein in imprinting and disease.

Developmental cell - 1 Oct 2008

Hirasawa Ryutaro, Feil Robert

Abstract excerpt

The monoallelic expression of imprinted genes is regulated by DNA methylation marks that originate from the oocyte or sperm. Li et al. (2008) show in this issue of Developmental Cell that the KRAB zinc finger protein Zfp57 contributes to the embryonic maintenance of these imprints. At one locus, Zfp57 is also involved in imprint establishment. These findings provide a mechanistic interpretation for Mackay et...

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Source

Identifiers

PMID: 18854130
DOI: 10.1016/j.devcel.2008.09.006

Genes

ZFP57

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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A KRAB domain zinc finger protein in imprinting and disease.PMID 18854130Read ↗

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ZFP57 dictates allelic expression switch of target imprinted genes.Semantic proximity Read ↗

Epigenetic regulation of unique genes and repetitive elements by the KRAB zinc finger protein ZFP57Semantic proximity Read ↗

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Zinc finger protein ZFP57 requires its co-factor to recruit DNA methyltransferases and maintains DNA methylation imprint in embryonic stem cells via its transcriptional repression domain.Semantic proximity Read ↗

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