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Article

A maternal-zygotic effect gene, Zfp57, maintains both maternal and paternal imprints.

Developmental cell - 1 Oct 2008

Li Xiajun, Ito Mitsuteru, Zhou Fen, Youngson Neil, Zuo Xiaopan, Leder Philip, Ferguson-Smith Anne C

Abstract excerpt

The mechanisms responsible for maintaining genomic methylation imprints in mouse embryos are not understood. We generated a knockout mouse in the Zfp57 locus encoding a KRAB zinc finger protein. Loss of just the zygotic function of Zfp57 causes partial neonatal lethality, whereas eliminating both the maternal and zygotic functions of Zfp57 results in a highly penetrant embryonic lethality. In oocytes, absence of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18854139
DOI: 10.1016/j.devcel.2008.08.014
PMCID: PMC2593089

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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