Article
Mitochondrial mutations and mitoepigenetics: Focus on regulation of oxidative stress-induced responses in breast cancers.
Seminars in cancer biology - 1 Aug 2022
Chen Kuo, Lu Pengwei, Beeraka Narasimha M, Sukocheva Olga A, Madhunapantula SubbaRao V, Liu Junqi, Sinelnikov Mikhail Y, Nikolenko Vladimir N, Bulygin Kirill V, Mikhaleva Liudmila M, Reshetov Igor V, Gu Yuanting, Zhang Jin, Cao Yu, Somasundaram Siva G, Kirkland Cecil E, Fan Ruitai, Aliev Gjumrakch
Abstract excerpt
Epigenetic regulation of mitochondrial DNA (mtDNA) is an emerging and fast-developing field of research. Compared to regulation of nucler DNA, mechanisms of mtDNA epigenetic regulation (mitoepigenetics) remain less investigated. However, mitochondrial signaling directs various vital intracellular processes including aerobic respiration, apoptosis, cell proliferation and survival, nucleic acid synthesis, and...
Topics
- Breast Neoplasms
- DNA, Mitochondrial
- Epigenesis, Genetic
- Female
- Humans
- Mutation
- Oxidative Stress
- Reactive Oxygen Species