Article
Sox7 controls arterial specification in conjunction with hey2 and efnb2 function.
Development (Cambridge, England) - 1 May 2015
Hermkens Dorien M A, van Impel Andreas, Urasaki Akihiro, Bussmann Jeroen, Duckers Henricus J, Schulte-Merker Stefan
Abstract excerpt
SoxF family members have been linked to arterio-venous specification events and human pathological conditions, but in contrast to Sox17 and Sox18, a detailed in vivo analysis of a Sox7 mutant model is still lacking. In this study we generated zebrafish sox7 mutants to understand the role of Sox7 during vascular development. By in vivo imaging of transgenic zebrafish lines we show that sox7 mutants display a short...
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