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Article

Sox18 Genetically Interacts With VegfC to Regulate Lymphangiogenesis in Zebrafish

22 Mar 2013

Abstract excerpt

OBJECTIVE: Lymphangiogenesis is regulated by transcription factors and by growth factor pathways, but their interplay has not been extensively studied so far. We addressed this issue in zebrafish. APPROACH AND RESULTS: Mutations in the transcription factor-coding gene SOX18 and in VEGFR3 cause lymphedema, and the VEGFR3/Flt4 ligand VEGFC plays an evolutionarily conserved role in lymphangiogenesis. Here, we report...

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Identifiers

PMID: 23520166
DOI: 10.1161/atvbaha.112.300254

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Related research

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Research trail→

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Sox18 Genetically Interacts With VegfC to Regulate Lymphangiogenesis in ZebrafishPMID 23520166Read ↗

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Mutations in the transcription factor gene SOX18 underlie recessive and dominant forms of hypotrichosis-lymphedema-telangiectasia.Semantic proximity Read ↗

mafba is a downstream transcriptional effector of Vegfc signaling essential for embryonic lymphangiogenesis in zebrafish.Semantic proximity Read ↗

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Development of the Zebrafish Lymphatic System Requires Vegfc SignalingSemantic proximity Read ↗

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