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Article

Sox18 and Sox7 play redundant roles in vascular development.

Blood - 1 Mar 2008

Cermenati Solei, Moleri Silvia, Cimbro Simona, Corti Paola, Del Giacco Luca, Amodeo Roberta, Dejana Elisabetta, Koopman Peter, Cotelli Franco, Beltrame Monica

Abstract excerpt

Mutations in SOX18 cause the human hypotrichosis-lymphedema-telangiectasia (HLT) syndrome. Their murine counterparts are the spontaneous ragged mutants, showing combined defects in hair follicle, blood vessel, and lymphatic vessel development. Mice null for Sox18 display only mild coat defects, s...

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Share to Animals, Genetically Modified
Share to Blood Vessels
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to SOXF Transcription Factors

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Source

Identifiers

PMID: 18094332
DOI: 10.1182/blood-2007-07-100412

Genes

SOX18

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18094332-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sox18 and Sox7 play redundant roles in vascular development.PMID 18094332Read ↗

Zebrafish Sox7 and Sox18 function together to control arterial-venous identity.Semantic proximity Read ↗

Vascular defects in a mouse model of hypotrichosis-lymphedema-telangiectasia syndrome indicate a role for SOX18 in blood vessel maturationSemantic proximity Read ↗

Sox18 Genetically Interacts With VegfC to Regulate Lymphangiogenesis in ZebrafishSemantic proximity Read ↗

Mutations in the transcription factor gene SOX18 underlie recessive and dominant forms of hypotrichosis-lymphedema-telangiectasia.Semantic proximity Read ↗

SOX18 and the transcriptional regulation of blood vessel development.Semantic proximity Read ↗

VEGFD regulates blood vascular development by modulating SOX18 activitySemantic proximity Read ↗

Sox7 controls arterial specification in conjunction with hey2 and efnb2 function.Semantic proximity Read ↗

Hypotrichosis-lymphedema-telangiectasia syndrome: Report of ileal atresia associated with a SOX18 de novo pathogenic variant and review of the phenotypic spectrum.Semantic proximity Read ↗

Sox18 induces development of the lymphatic vasculature in miceSemantic proximity Read ↗

Sox7 and Sox17 are strain-specific modifiers of the lymphangiogenic defects caused by Sox18 dysfunction in mice.Semantic proximity Read ↗

The blood vasculature instructs lymphatics patterning in a SOX7 dependent mannerSemantic proximity Read ↗

Redundant roles of Sox17 and Sox18 in early cardiovascular development of mouse embryos.Semantic proximity Read ↗

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