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Article

Specification of arterial, venous, and lymphatic endothelial cells during embryonic development.

1 May 2010

Abstract excerpt

The groundbreaking discovery about arterial and venous expression of ephrinB2 and EphB4, respectively, in early embryonic development has led to a new paradigm for vascular research, providing compelling evidence that arterial and venous endothelial cells are established by genetic mechanisms before circulation begins. For arterial specification, vascular endothelial growth factor (VEGF) induces expression of...

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PMID: 20238301
DOI: 10.14670/hh-25.637

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