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Article

HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development

9 Jul 2018

Abstract excerpt

Formation of the lymphatic system requires the coordinated expression of several key regulators: vascular endothelial growth factor C (VEGFC), its receptor FLT4, and a key transcriptional effector, PROX1. Yet, how expression of these signaling components is regulated remains poorly understood. Here, using a combination of genetic and molecular approaches, we identify the transcription factor hematopoietically...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 30006544
DOI: 10.1038/s41467-018-05039-1

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