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Article

14-3-3 proteins restrain the Exo1 nuclease to prevent overresection.

The Journal of biological chemistry - 8 May 2015

Chen Xiaoqing, Kim In-Kwon, Honaker Yuchi, Paudyal Sharad C, Koh Won Kyun, Sparks Melanie, Li Shan, Piwnica-Worms Helen, Ellenberger Tom, You Zhongsheng

Abstract excerpt

The DNA end resection process dictates the cellular response to DNA double strand break damage and is essential for genome maintenance. Although insufficient DNA resection hinders homology-directed repair and ATR (ataxia telangiectasia and Rad3 related)-dependent checkpoint activation, overresect...

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Source

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Identifiers

PMID: 25833945
DOI: 10.1074/jbc.M115.644005
PMCID: PMC4424361

Genes

PCNA
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25833945-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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