Article
The PIN domain of EXO1 recognizes poly(ADP-ribose) in DNA damage response.
Nucleic acids research - 15 Dec 2015
Zhang Feng, Shi Jiazhong, Chen Shih-Hsun, Bian Chunjing, Yu Xiaochun
Abstract excerpt
Following DNA double-strand breaks, poly(ADP-ribose) (PAR) is quickly and heavily synthesized to mediate fast and early recruitment of a number of DNA damage response factors to the sites of DNA lesions and facilitates DNA damage repair. Here, we found that EXO1, an exonuclease for DNA damage repair, is quickly recruited to the sites of DNA damage via PAR-binding. With further dissection of the functional domains...
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