Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Plexin D1 determines body fat distribution by regulating the type V collagen microenvironment in visceral adipose tissue.

Proceedings of the National Academy of Sciences of the United States of America - 7 Apr 2015

Minchin James E N, Dahlman Ingrid, Harvey Christopher J, Mejhert Niklas, Singh Manvendra K, Epstein Jonathan A, Arner Peter, Torres-Vázquez Jesús, Rawls John F

Abstract excerpt

Genome-wide association studies have implicated PLEXIN D1 (PLXND1) in body fat distribution and type 2 diabetes. However, a role for PLXND1 in regional adiposity and insulin resistance is unknown. Here we use in vivo imaging and genetic analysis in zebrafish to show that Plxnd1 regulates body fat distribution and insulin sensitivity. Plxnd1 deficiency in zebrafish induced hyperplastic morphology in visceral...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Composition
Share to Cell Adhesion Molecules, Neuronal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Collagen Type V

Share to Endothelial Cells

Share to Extracellular Matrix

Share to Intra-Abdominal Fat

Share to Lipids

Share to Zebrafish

Source

Open in PubMed Open full text

Identifiers

PMID: 25831505
DOI: 10.1073/pnas.1416412112
PMCID: PMC4394244

Genes

PLXND1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Plexin D1 determines body fat distribution by regulating the type V collagen microenvironment in visceral adipose tissue.PMID 25831505Read ↗

Human genetic studies and zebrafish models identify Plxna4 as a regulator of adiposity, somatic growth, and feeding behavioursSemantic proximity Read ↗

A quantitative in vivo CRISPR-imaging platform identifies regulators of hyperplastic and hypertrophic adipose morphology in zebrafishSemantic proximity Read ↗

Deep phenotyping in zebrafish reveals genetic and diet-induced adiposity changes that may inform disease risk.Semantic proximity Read ↗

CRISPR/Cas9-induced LEAP2 and GHSR1a knockout mutant zebrafish displayed abnormal growth and impaired lipid metabolism.Semantic proximity Read ↗

FAM13A affects body fat distribution and adipocyte function.Semantic proximity Read ↗

Leptin deficiency affects glucose homeostasis and results in adiposity in zebrafishSemantic proximity Read ↗

RNA-Seq Analysis of Abdominal Fat in Genetically Fat and Lean Chickens Highlights a Divergence in Expression of Genes Controlling Adiposity, Hemostasis, and Lipid Metabolism.Semantic proximity Read ↗

Tcf7l2 plays pleiotropic roles in the control of glucose homeostasis, pancreas morphology, vascularization and regeneration.Semantic proximity Read ↗

Characteristic Expression of Extracellular Matrix in Subcutaneous Adipose Tissue Development and Adipogenesis; Comparison with Visceral Adipose TissueSemantic proximity Read ↗

EHD2-mediated restriction of caveolar dynamics regulates cellular lipid uptakeSemantic proximity Read ↗

Dwarfism and Increased Adiposity in the gh1 Mutant Zebrafish vizziniSemantic proximity Read ↗

Pathological Conversion of Mouse Perivascular Adipose Tissue by Notch Activation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.