Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dwarfism and Increased Adiposity in the gh1 Mutant Zebrafish vizzini

2 Mar 2013

Abstract excerpt

Somatic growth and adipogenesis are closely associated with the development of obesity in humans. In this study, we identify a zebrafish mutant, vizzini, that exhibits both a severe defect in somatic growth and increased accumulation of adipose tissue. Positional cloning of vizzini revealed a premature stop codon in gh1. Although the effects of GH are largely through igfs in mammals, we found no decrease in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue and Metabolism
Share to Regulation of Appetite and Obesity
Share to Zebrafish Biomedical Research Applications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23456361
DOI: 10.1210/en.2012-1734

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dwarfism and Increased Adiposity in the gh1 Mutant Zebrafish vizziniPMID 23456361Read ↗

Vitamin D deficiency serves as a precursor to stunted growth and central adiposity in zebrafishSemantic proximity Read ↗

CRISPR/Cas9-induced LEAP2 and GHSR1a knockout mutant zebrafish displayed abnormal growth and impaired lipid metabolism.Semantic proximity Read ↗

Genomic knockout of <i>alms1</i> in zebrafish recapitulates Alström syndrome and provides insight into metabolic phenotypesSemantic proximity Read ↗

Deep phenotyping in zebrafish reveals genetic and diet-induced adiposity changes that may inform disease risk.Semantic proximity Read ↗

A quantitative in vivo CRISPR-imaging platform identifies regulators of hyperplastic and hypertrophic adipose morphology in zebrafishSemantic proximity Read ↗

A zebrafish model of growth hormone insensitivity syndrome with immune dysregulation 1 (GHISID1).Semantic proximity Read ↗

Human genetic studies and zebrafish models identify Plxna4 as a regulator of adiposity, somatic growth, and feeding behavioursSemantic proximity Read ↗

Long-Term Hyperphagia and Caloric Restriction Caused by Low- or High-Density Husbandry Have Differential Effects on Zebrafish Postembryonic Development, Somatic Growth, Fat Accumulation and ReproductionSemantic proximity Read ↗

Long-term obesogenic diet leads to metabolic phenotypes which are not exacerbated by catch-up growth in zebrafish.Semantic proximity Read ↗

Postnatal<i>Sim1</i>Deficiency Causes Hyperphagic Obesity and Reduced<i>Mc4r</i>and<i>Oxytocin</i>ExpressionSemantic proximity Read ↗

Creation of a genetic model of obesity in a teleostSemantic proximity Read ↗

Tmem263 deletion disrupts the GH/IGF-1 axis and causes dwarfism and impairs skeletal acquisitionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.