Article

EHD2-mediated restriction of caveolar dynamics regulates cellular lipid uptake

2019-01-04

Abstract excerpt

Epsl5-homology domain containing protein 2 (EHD2) is a dynamin-related ATPase located at the neck of caveolae, but its physiological function has remained unclear. Here, we found that global genetic ablation of EHD2 in mice led to increased fat accumulation. This organismic phenotype was paralleled at the cellular level by increased lipid uptake via a caveolae-, dynamin- and CD36-dependent pathway, an elevated num...

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Literature Corpus work: 4463e3cf-cba2-534d-a891-dc6c1baf669f
DOI: 10.1101/511709

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