Leptin deficiency affects glucose homeostasis and results in adiposity in zebrafish

Abstract excerpt

Leptin is a hormone which functions in the regulation of energy homeostasis via suppression of appetite. In zebrafish, there are two paralogous genes encoding leptin, called lepa and lepb. In a gene expression study, we found that the lepb gene, not the lepa gene, was significantly downregulated under the state of insulin-resistance in zebrafish larvae, suggesting that the lepb plays a role in glucose...

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• Share to Adipokines, Inflammation, and Metabolic Diseases
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