Article
FAM13A affects body fat distribution and adipocyte function.
Nature communications - 19 Mar 2020
Fathzadeh Mohsen, Li Jiehan, Rao Abhiram, Cook Naomi, Chennamsetty Indumathi, Seldin Marcus, Zhou Xiang, Sangwung Panjamaporn, Gloudemans Michael J, Keller Mark, Attie Allan, Yang Jing, Wabitsch Martin, Carcamo-Orive Ivan, Tada Yuko, Lusis Aldons J, Shin Myung Kyun, Molony Cliona M, McLaughlin Tracey, Reaven Gerald, Montgomery Stephen B, Reilly Dermot, Quertermous Thomas, Ingelsson Erik, Knowles Joshua W
Abstract excerpt
Genetic variation in the FAM13A (Family with Sequence Similarity 13 Member A) locus has been associated with several glycemic and metabolic traits in genome-wide association studies (GWAS). Here, we demonstrate that in humans, FAM13A alleles are associated with increased FAM13A expression in subcutaneous adipose tissue (SAT) and an insulin resistance-related phenotype (e.g. higher waist-to-hip ratio and fasting...
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