Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hematopoietic stem cell quiescence and function are controlled by the CYLD-TRAF2-p38MAPK pathway.

The Journal of experimental medicine - 6 Apr 2015

Tesio Melania, Tang Yilang, Müdder Katja, Saini Massimo, von Paleske Lisa, Macintyre Elizabeth, Pasparakis Manolis, Waisman Ari, Trumpp Andreas

Abstract excerpt

The status of long-term quiescence and dormancy guarantees the integrity of hematopoietic stem cells (HSCs) during adult homeostasis. However the molecular mechanisms regulating HSC dormancy remain poorly understood. Here we show that cylindromatosis (CYLD), a tumor suppressor gene and negative r...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cysteine Endopeptidases
Share to Deubiquitinating Enzyme CYLD
Share to Hematopoietic Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MAP Kinase Signaling System

Share to Mice, Knockout

Share to NF-kappa B

Share to p38 Mitogen-Activated Protein Kinases

Share to TNF Receptor-Associated Factor 2

Source

Open in PubMed Open full text

Identifiers

PMID: 25824820
DOI: 10.1084/jem.20141438
PMCID: PMC4387289

Genes

CYLD
TRAF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25824820-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hematopoietic stem cell quiescence and function are controlled by the CYLD-TRAF2-p38MAPK pathway.PMID 25824820Read ↗

Lack of the ubiquitin-editing enzyme A20 results in loss of hematopoietic stem cell quiescence.Semantic proximity Read ↗

Loss of Cbl and Cbl-b ubiquitin ligases abrogates hematopoietic stem cell quiescence and sensitizes leukemic disease to chemotherapySemantic proximity Read ↗

CYLD-Mediated Signaling and DiseasesSemantic proximity Read ↗

PLZF mutation alters mouse hematopoietic stem cell function and cell cycle progression.Semantic proximity Read ↗

Cited2 Is an Essential Regulator of Adult Hematopoietic Stem CellsSemantic proximity Read ↗

Nuclear DEK preserves hematopoietic stem cells potential via NCoR1/HDAC3-Akt1/2-mTOR axisSemantic proximity Read ↗

NPMc+ and Flt3-ITD cooperation promotes a new oncogenic HSC state that supports transformation and leukemia stem cell maintenanceSemantic proximity Read ↗

Thymocyte-specific truncation of the deubiquitinating domain of CYLD impairs positive selection in a NF-kappaB essential modulator-dependent manner.Semantic proximity Read ↗

Cooperation between both Wnt/{beta}-catenin and PTEN/PI3K/Akt signaling promotes primitive hematopoietic stem cell self-renewal and expansion.Semantic proximity Read ↗

Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD-induced myeloproliferation.Semantic proximity Read ↗

TRAF6 functions as a tumor suppressor in myeloid malignancies by directly targeting MYC oncogenic activity.Semantic proximity Read ↗

Mitofusin 2 maintains haematopoietic stem cells with extensive lymphoid potentialSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.