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Article

Cited2 Is an Essential Regulator of Adult Hematopoietic Stem Cells

1 Dec 2009

Abstract excerpt

The regulatory pathways necessary for the maintenance of adult hematopoietic stem cells (HSCs) remain poorly defined. By using loss-of-function approaches, we report a selective and cell-autonomous requirement for the p300/CBP-binding transcriptional coactivator Cited2 in adult HSC maintenance. Conditional deletion of Cited2 in the adult mouse results in loss of HSCs causing multilineage bone marrow failure and...

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PMID: 19951693
DOI: 10.1016/j.stem.2009.11.001

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