Article
TRAF6 functions as a tumor suppressor in myeloid malignancies by directly targeting MYC oncogenic activity.
Cell stem cell - 3 Feb 2022
Muto Tomoya, Guillamot Maria, Yeung Jennifer, Fang Jing, Bennett Joshua, Nadorp Bettina, Lasry Audrey, Redondo Luna Zea, Choi Kwangmin, Gong Yixiao, Walker Callum S, Hueneman Kathleen, Bolanos Lyndsey C, Barreyro Laura, Lee Lynn H, Greis Kenneth D, Vasyliev Nikita, Khodadadi-Jamayran Alireza, Nudler Evgeny, Lujambio Amaia, Lowe Scott W, Aifantis Iannis, Starczynowski Daniel T
Abstract excerpt
Clonal hematopoiesis (CH) is an aging-associated condition characterized by the clonal outgrowth of pre-leukemic cells that acquire specific mutations. Although individuals with CH are healthy, they are at an increased risk of developing myeloid malignancies, suggesting that additional alterations are needed for the transition from a pre-leukemia stage to frank leukemia. To identify signaling states that...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.