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Article

An ATPase-deficient variant of the SNF2 family member HELLS shows altered dynamics at pericentromeric heterochromatin.

Journal of molecular biology - 22 May 2015

Lungu Cristiana, Muegge Kathrin, Jeltsch Albert, Jurkowska Renata Z

Abstract excerpt

The HELLS (helicase, lymphoid specific, also known as lymphoid-specific helicase) protein is related to the SNF2 (sucrose non-fermentable 2) family of chromatin remodeling ATPases. It is required for efficient DNA methylation in mammals, particularly at heterochromatin-located repetitive sequences. In this study, we investigated the interaction of HELLS with chromatin and used an ATPase-deficient HELLS variant to...

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Share to Adenosine Triphosphatases
Share to DNA Helicases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Fluorescence Recovery After Photobleaching

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Source

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Identifiers

PMID: 25823553
DOI: 10.1016/j.jmb.2015.03.014
PMCID: PMC7722765

Genes

HELLS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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